The Art of Subtraction: A Structured Clinical Approach to Deprescribing in Complex Medication Regimens
As polypharmacy continues to rise among aging and medically complex US patients, deprescribing has emerged as a critical—and underutilized—clinical skill. This roadmap walks prescribers through evidence-based protocols for identifying inappropriate medications, managing discontinuation safely, and communicating treatment changes in ways that preserve patient trust and reduce medicolegal exposure.